Early double-defibrillation in out-of-hospital cardiac arrest
News
We welcome Värmland!
We’re delighted to share that Region Värmland is now part of DoubleD-Trial. Starting today, EMS Värmland is actively recruiting patients, lead by local PI Linus Lilja. We give a warm
Welcome NU Hospital Group!
We are happy to announce that NU Hospital Group (NU-sjukvården, Trollhättan area, Sweden) in Västra Götaland Region are up and running with local PI Carl Magnusson and local study coordinators
🚑 New Site Activation – Södra Älvsborgs Sjukhus (SÄS), Borås, Sweden!
We are thrilled to announce that Södra Älvsborgs Sjukhus (SÄS) in Borås has officially joined the Double-D Trial family! As of today, the SÄS EMS team have begun enrolling patients,
Video demonstration of intervention
How to perform double-defibrillation
Main Trial LIVE!
DoubleD-Trial is an academic, investigator initiated, open label, randomized trial.
The main purpose of the trial is to assess survival after early double sequential defibrillation (DSD), compared to standard defibrillation, in patients with Out of Hospital Cardiac Arrest (OHCA), with initial shockable rhythm who remain in cardiac arrest after at least one standard defibrillation.
The trial is coordinated by the Centre for resuscitation science, Karolinska Institutet (sponsor).
Screening for inclusion will be performed in all OHCA by participating emergency medical services (EMS) units where there are two study-specific defibrillators available onsite (at the moment Corpuls3, additional defibrillators will be added). All OHCA patients (>18 years) with VT/VF at rhythm analysis withat least one defibrillation performed in standard A-L position are screened for inclusion. The pilot study enrolling n= 40 patients in West Sweden was completed in April 2025. Read more
The main study started recruiting patients during September 2025
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