Early double-defibrillation in out-of-hospital cardiac arrest
Main Trial Going LIVE!
DoubleD-Trial is an academic, investigator initiated, open label, randomized trial.
The main purpose of the trial is to assess survival after early double sequential defibrillation (DSD), compared to standard defibrillation, in patients with Out of Hospital Cardiac Arrest (OHCA), with initial shockable rhythm who remain in cardiac arrest after at least one standard defibrillation.
The trial is coordinated by the Centre for resuscitation science, Karolinska Institutet (sponsor).
Screening for inclusion will be performed in all OHCA by participating emergency medical services (EMS) units where there are two study-specific defibrillators available onsite (at the moment Corpuls3, additional defibrillators will be added). All OHCA patients (>18 years) with VT/VF at rhythm analysis withat least one defibrillation performed in standard A-L position are screened for inclusion. The pilot study enrolling n= 40 patients in West Sweden was completed in April 2025. Read more
The main study will start recruiting patients within the month of September! Read more
News
We are live and recruiting!
We are happy to announce that as of this morning we are live and recruiting patients at Sahlgrenska University and Prehospital Intensive Care area in
Inclusion starting for main trial!
The DoubleD-trial is planned to start including on Monday, September 8th! First to recruit will be Sahlgrenska University Hospital with their prehospital ICU and following